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Maximize Muscle Protein
Synthesis & Maximize Muscle Mass! Part-2
In the previous article I reported that exercise science research
has now confirmed some important breakthroughs in obtaining the
most from all of those jaw-clenched, teeth-grinding hours spent
in the gym.
That is, the stimulation of muscle protein synthesis (MPS) is the
critical regulatory event that leads to muscle growth [1,2,]. Without
a high stimulation of MPS, muscle gains just won’t happen. It is
also clear that the degree of overload (amount of weight used) determines
the magnitude of stimulation of MPS and subsequent gains in muscle
mass [7]. In this article we'll deal specifically with the research
that leads us to the most effective weight lifting program that
stimulates MPS and accelerates muscle mass gains.
If we look to the classical prescription for gaining muscle mass,
that is, muscle size is directly proportional to the magnitude of
functional overload [8,9]. This fundamental aspect of building muscle
has been around for over 20 years but its been buried in the hype
and bullshit that is the bodybuilding magazine industry. I mean,
imagine trying to sell 12 magazines every year with just that
piece of information? It's not the most stylish, sexy scoop
is it? But if you're really serious about quality gains from every
workout then you'd be getting excited by now. This information leads
us to rule number three in our Building Muscle Mass 101
course.
It's a question of strength
If research has confirmed that the stimulation of MPS comes down
to the amount of overload placed on muscle, then obviously, strength
will determine the amount of overload used. A person’s strength
becomes the limiting factor in their potential to build muscle.
More particularly, improvements in strength will enable greater
overload to be placed on muscle. In turn, this provides a consistently
greater stimulus for MPS and muscle growth.
Previously, you may have thought you understood the importance
of building strength for gaining muscle, but now you know the science-based
reason why!
The relationship between muscle size and strength is clear. Exercise
scientists have known for a long time that maximum voluntary strength
is closely associated with muscle size [10]. Texts books on resistance
training tell us that muscle fibers in general, show a linear relationship
between their cross-sectional area (size) and the amount of force
they can generate. It is true that a number of factors may influence
the expression of strength. However, I previously explained two
universal rules that do not change. The first was that stimulating
a high rate of MPS is the only way to stimulate muscle gains. The
second was that load determines the degree of stimulation of MPS
[6].
Rule number three; improvements in strength enable greater overload. Greater overload means a higher stimulation of MPS and more muscle mass. A clear focus on building strength ensures that mass will follow.
In terms of exercise prescription for gaining muscle mass, all the science-based information on this topic basically suggests that if a weight lifting program focuses on increasing strength, it will ultimately result in an increase in muscle mass. New improvements in strength enable greater overload to be placed on the muscle(s) and therefore, provide further potential for hypertrophy. It’s a pretty straight forward concept that a lot more gym buffs would do well to take on board. I mean in all my years visiting gyms, I’ve never seen a skinny guy bench press 400 pounds!
Training to become physically stronger enhances your potential for hypertrophy. Conversely, its extremely difficult to pack on muscle mass without significant gains in strength.
However, many bodybuilders are confused about this basic relationship. Its no wonder when you take a look at the recommendations made by many of the organizations that we look to for resistance training accreditation and resource information.
A mass of confusion about building muscle mass!
Organizations such as the American College of Sports Medicine (ACSM) and the National Strength & Conditioning Association (NSCA) have attempted to distinguish differences between weight lifting for strength as opposed to building muscle (hypertrophy-specific training). Yet as I have shown you, a science-based distinction between the two is very difficult. The principles of one are intertwined within the other. As a consequence, in an effort to provide clear distinctions in their exercise recommendations for strength training as opposed to hypertrophy-specific training, these organizations have drawn on some rather flimsy evidence to justify their recommendations.
For example, the guidelines for strength and hypertrophy development recommended by ACSM are very similar in most respects such as exercise selection and training frequency. However, things get a little confusing when it comes to the recommendations for loading (RMs) and training volume. For strength development, the ACSM recommends the use of maximum loads (1-6RM), a lower number of total work sets and long rest intervals (3 to 5 minutes) between working sets. However, when it comes to “hypertrophy-specific” training they recommend the incorporation of lighter loads (8-12RM), more volume and shorter rest intervals. In light of the fundamental principles I’ve presented to you thus far, I fail to see how this recommendation could be more effective for building muscle than the recommendations made for building strength?
The justification the ACSM provides for these hypertrophy-specific training recommendations is that a higher increase of some anabolic hormone concentrations (in the blood) have been observed by this type of training [12]. This isn’t totally correct. Other studies [11] have shown a higher increase in circulating anabolic hormone concentrations with a low volume, high overload, traditional strength training approach. Above all, at the time these recommendations were published (three years ago), the authors knew that the significance of any minor differences in acute hormone responses was a moot point. No physiological consequences (such as improvements strength or muscle mass) had been documented.
The recommendations for bodybuilding training made by the NSCA are even worse. In their accreditation text, the NSCA recommend the use of up to 20 working sets per muscle group! The use of moderate loads (as opposed to heavy loads) and one minute rest intervals between sets [13]. That’s not bodybuilding training, that’s circuit training!
No longitudinal studies are provided that may substantiate these rather definitive recommendations. However, things get really confusing when in a different chapter of the very same text, the author states It would appear from recent studies that heavy loads, in the 3-5RM range, are most effective in stimulating growth of all muscle fibers because all types are recruited.[14] Confused? Me too!
The aspect of rest intervals between sets is a particularly contentious issue with me. Any aspect of training that limits the amount of overload you place on muscle is going to short-circuit the potential for muscle growth. If we look to the research on the topic of rest intervals, it is crystal clear that short rest intervals (one minute or less) between sets reduce workout performance and reduce the ability to overload the muscle.
Weight lifting workout performance is defined as the total number of repetitions completed in a predetermined amount of sets with a designated load. Workout performance is shown to be compromised with short rest periods (30-60 seconds) and improved by longer rest intervals (such as two three minutes), particularly when complex exercises are involved; squats, bench presses, deadlifts, rows etc [15,16]. In fact, some longitudinal resistance training studies have shown greater strength gains with longer versus shorter rest intervals between sets (two-three minutes vs. 30-40 seconds) [17, 18].
The results of a recent study smash these hypertrophy-specific training recommendations completely.
A recent 6 month long training study has confirmed that the use of lighter weight, more reps and shorter rest intervals was no more effective than a traditional strength training program in terms of anabolic hormone responses, strength or muscle mass gains [19]. In fact, in this cross-over study, when the bodybuilders followed the high overload approach that utilized longer rest intervals (up to 5 minutes between heavy sets), they experienced better strength gains. The traditional strength training program stimulated just as much muscle growth as the hypertrophy-specific program.
I’ve worked in the fitness industry for a long time, and my concern has always been the lack of credibility that inaccurate/unfounded training recommendations create within the industry. For example, where do these “hypetrophy specific” recommendations leave the average gym instructor or personal trainer who needs to know the best way to train their clients? Where does this leave the average Joe who listens to these professionals to gain the best advice for building muscle? Do you think both groups would be confused or frustrated? You bet.
Now, for the record, I am a proud member of both the NSCA and the ACSM. The points I’ve made are not derogatory toward these excellent organizations. In many ways they have bought the science of weight lifting out of the dark ages and into a highly professional realm. My point is that building muscle has become an important issue. Sarcopenia (muscle loss in aging) costs the United States health care system $18 billion dollars a year. We need clear, uniform guidelines based on the latest research available to combat a problem that is going to reach epidemic proportions in an ageing population. The “hypertrophy-specific training recommendations made by the NSCA, ACSM and other organizations must be up dated to comply with the research that is most relevant to this topic. It’s as simple as that.
The research-based exercise prescription for gaining muscle mass.
If we can step back into the real world for a moment, back to what science can really tells us about an effective way to train to build muscle. It all comes down to overload and the stimulation of MPS; the critical regulatory event that leads to muscle growth. However, it may interest you to know that less than a handful of weight training studies have actually assessed the effects of different training protocols on muscle hypertrophy. Of these, not one has shown that the use of “moderate” loads is more effective than the use of heavy loads to build muscle. Not one has shown that shorter rest intervals build more muscle than taking longer rest intervals. In term of training volume and frequency, there is no data on hypertrophy responses other than the old “3 working sets are better than one” finding. While it is clear that performing more than one working set on a muscle group is required, no studies have determine how many sets, per workout maybe optimal for muscle growth.
The lack of research data on a dose-response relationship for training and muscle hypertrophy is about as clear as Charlie Sheen’s ability to be monogamous. (Yeah, it’s that bad). The only research-based, quantifiable prescription for training volume can be found in recent meta-analyses on strength development (Rhea et al., 2003; Peterson et al., 2004). Meta-analyses research can be very useful as it groups all the results from relevant studies on a particular topic and statistically, provides the conclusions of all this research. The reports on a dose-response relationship between training volume and optimum strength development provide some interesting results.
These studies report that trained or advanced individuals (as opposed to novices) obtain the best strength gains by using a high overload approach; 80 to 85% of the one-rep max (which would equate to a maximal rep range of around 3-6 RM). Each muscle group should be trained twice a week with a total of only 4 to 8 working (non-warm up) sets per muscle group each workout [20,21]. Remember, optimum strength development is important; strength improvements clearly increase the potential for muscle mass gains.
Many bodybuilders and strength athletes fail to understand that it’s impossible to isolate muscles during training. Anyone that performs a training day that involves the chest muscles and another day devoted to the arm and/or shoulder muscles automatically ensures that these muscle groups receive two workouts a week. If you’re a bodybuilder that typically performs a “chest day”, a “back day” and an “arm day” each week then your shoulder muscles, (traps and delts) are worked at least three times a week no matter what exercises you perform. Same can be said for legs and back muscles. That is, the deadlifts you perform on “back day” will always involve the hip and leg muscles. The variety of squats you perform on “leg day” also recruit the back muscles heavily. Therefore, with regard to the current research-based prescription for optimum training volume for strength development, hopefully you can see how easy it is to over train.
To summarize what research can tell us about an optimum training prescription for muscle growth; overload appears to be the fundamental aspect. In particular, the amount of overload placed on muscle determines the magnitude of stimulation of MPS and any subsequent gain in muscle mass.
Therefore, weight training programs designed to maximize muscle growth must use protocols that ensure maximum overload and focus on strength development. That means selecting only those exercises, repetition ranges and rest intervals that enable maximum overload. In terms of volume and frequency, the research on optimizing strength development reveals that less is more beneficial than many “experts” will have you believe. Train muscle groups no more than twice a week with a total of only 4 to 8 working sets each workout.
The funny thing is, AST has been prescribing these exact recommendations
in the, Max-OT program for
many years. The research side of things is finally catching up. Max-OT is
a free-access program that has proven incredibly effective to many that
desire the best results in the shortest possible amount of time. Isn’t that
what training is all about?
Check out Max-OT here.
Next month we’ll look at specific nutritional strategies you can employ every day to stimulate MPS and accelerate muscle mass gains.
References
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